Neprinol and Fibrin

Neprinol and Fibrin

Enzymes can be thought of as proteins on a mission to improve your health.  The most destructive target an enzyme can seek-and-destroy is a fibrous protein called fibrin. Neprinol contains a powerful combination of fibrin-dissolving enzymes like serrapeptase, nattokinase and bromelain, as well as other natural ingredients. That is why it is known as Neprinol AFD – Advanced Fibrin Defense®.

But to understand why the body needs help defending itself against fibrin you first need to understand a bit more about the protein itself.

Fibrin

Fibrin is an insoluble protein that plays a major role in the formation of blood clots and scar tissue. During the blood clotting process, the soluble protein fibrinogen converts into insoluble fibrin, which is then laid down inside the damaged blood vessel. The fibrin strands then assemble into a net-like gel that hardens and captures all of the materials necessary to patch the damaged vessel. This is the structural framework of a blood clot.

Obviously, fibrin plays a vital role in the healing process; however, when there is fibrin overproduction, it can lead to the formation of dangerous and unnecessary blood clots in the body [1]. One factor that can lead to excessive fibrin is aging.

As we age, the concentration of fibrinogen increases in our blood [2]. High levels of fibrinogen increases fibrin production, and as fibrin begins to accumulate in the blood vessels it generally leads to the formation of blood clots [3]. Healthy individuals usually have sufficient levels of plasmin, an enzyme that breaks up fibrin blood clots. Unfortunately plasmin production slows down as we get older so the normal process of removing excess fibrin is reduced. The result of this can be cardiovascular disease, heart attacks, strokes, pulmonary emboli, deep vein thrombosis (DVT) and other related disorders [4-8].

Neprinol

Research has shown that protein-dissolving enzymes like those found in Neprinol can slow the production of fibrin and enhance its removal from the body [1]. Neprinol’s blend of enzymes generally tests well above 50,000 FU per gram, which means that 50,000 units of fibrin are broken down by each gram of Neprinol powder. Of the enzymes contained in this formula perhaps the most significant is nattokinase, which has been shown to be four times more powerful than our body’s own plasmin at breaking down blood clots [9].

Nattokinase

Nattokinase is an enzyme extracted from natto, a fermented soybean ‘cheese’ that is popular in Japan [10]. The ability of nattokinase to breakdown fibrin has been tested inmore than 12 studies [11], and nattokinase has been shown to be the most potent fibrin-degrading enzyme out of more than 200 foods tested [3].

Researchers have found that nattokinase works much in the same way as plasmin [3], which means that nattokinase literally dissolves fibrin, whether it is holding together blood clots or is part of scar tissue [12]. However, nattokinase also blocks the activity of plasminogen activator inhibitor 1 (PAI-1), which boosts its fibrin-destroying capabilities even more [9,13].

Plasminogen is made into plasmin, the body’s fibrin-dissolving enzyme. However, the conversion process is inactivated by PAI-1. This is why high levels of PAI-1 reduce fibrin breakdown and removal [14]. Nattokinase increases fibrin breakdown by blocking PAI-1 so that more plasmin is produced.

Because of this nattokinase is not only able to stop dangerous blood clots from developing but also helps dissolve any clots that have already formed. As a result, oral nattokinase supplements are recommended for preventing cardiovascular disease [15]. Nattokinase has also been shown to reduce the risk of deep vein thrombosis (DVT) in high-risk patients in combination with pycnogenol [16].

Bromelain

Bromelain is an extract from pineapple that contains a number of fibrin-degrading enzymes [17,18], as well as enzymes that enhance this fibrin-dissolving action [19]. Bromelain was shown to increase the conversion of plasminogen into plasmin [20-22]. It has also been shown to prevent the conversion of fibrinogen to fibrin [17]. However, unlike nattokinase, bromelain is not able to dissolve fibrin clumps that have already formed [17].

Because a high percentage of ingested bromelain is absorbed intact into the bloodstream, protein- and fibrin-degrading activity in the blood can be increased for hours after taking it [23]. Two large-scale trials in patients with heart problems showed that bromelain could almost completely eliminate thrombosis [24].

Serrapeptase

Serrapeptase is another important component of Neprinol’s advanced fibrin defense. Serrapeptase is a protein-degrading enzyme isolated from the silk worm [25]. It has significant anti-inflammatory and fibrin-removal activity [26], which makes it ideal for preventing blood clot formation associated with cardiovascular disease. To find out even more about the many benefits of serrapeptase please visit www.Serrapeptase.Org.

Other Diseases Linked to Fibrin

The buildup of excess fibrin in the body can cause more health problems than just blood clots. Fibrin has also been linked to a number of chronic and progressive diseases like multiple sclerosis [27,28] and asthma [29]. As a result, Neprinol’s fibrin-degrading enzymes could prove to be a good treatment option [1,30].

Breaking down fibrin using enzymes may also help a number of conditions that are difficult to treat, such as Peyronie’s disease, Dupuytren’s contracture and Ledderhose’s disease. All of these conditions are characterized by a loss of tissue elasticity, which leads to tissue tearing, then bleeding, clot formation and fibrin deposition. Over time, taking fibrin-degrading enzymes may reduce the amount of scar tissue built up in locations where there has been repeated damage and bleeding [1].

Finally, using enzymes to dissolve fibrin may also play a role in cancer prevention and treatment. Cancer cells often are surrounded by a fibrin coating [31]. Researchers think that the fibrin may provide a type of camouflage for these abnormal cells, allowing them to escape being destroyed by the immune system. It is possible that by removing this fibrin coating, the body could detect cancer cells and destroy them before they are able to gain a foothold in the body.

Advanced Fibrin Defense

As you can see, excess fibrin can wreak havoc on our bodies, especially as we get older and our natural production of enzymes decreases. However, Neprinol provides a combination of superior fibrin-active enzymes designed to keep fibrin levels in check. Neprinol is an excellent choice for anyone suffering from, or hoping to prevent, the harmful effects of excess fibrin.

References:

1. Meletis CD, Barker JE. Therapeutic enzymes: using the body’s helpers as healers. Alt Comp Ther. 2005;74-77.
2. Meade TW. Fibrinogen and cardiovascular disease. J Clin Pathol. 1997;50:13-15.
3. Milner M, Makise K. Natto and its Active Ingredient Nattokinase: a potent and safe thrombolytic agent. Alt Comp Therap. 2002;8(3):157-164.
4. Koenig W. Fibrin(ogen) in cardiovascular disease: an update. Thromb Haemost. 2003;89:601-609.
5. Lefevre M, Kris-Etherton PM, Zhao G, Tracy RP. Dietary fatty acids, hemostasis, and cardiovascular disease risk. J Am Diet Assoc. 2004;104:410-419.
6. Kannel WB. Overview of hemostatic factors involved in atherosclerotic cardiovascular disease. Lipids. 2005;40:1215-1220.
7. Eidelman RS, Hennekens CH. Fibrinogen: a predictor of stroke and marker of atherosclerosis. Eur Heart J. 2003;24:499-500.
8. Nesheim M. Myocardial infarction and the balance between fibrin deposition and removal. Ital Heart J. 2001;2:641-645.
9. Fujita M, Hong K, Ito Y, et al. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull. 1995;18:1387-1391.
10. Sumi H, Hamada H, Tsushima H, Mihara H, Muraki H. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet. Experientia. 1987;43:1110-1111.
11. Pais E, Alexy T, Holsworth RE Jr, Meise HJ. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin Hemorheol Microcirc. 2006;35:139-142.
12. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol. 1990;84:139-143.
13. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci. 2003;73:1289-1298.
14. Hamsten A, de Faire U, Walldius G, et al. Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction. Lancet. 1987;2:3-9.
15. Hsia C-H, Shen M-C, Lin J-S, et al. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutr Res. 2009;29:190-196.
16. Cesarone MR, Belcaro G, Nicolaides AN, et al. Prevention of venous thrombosis in long-haul flights with Flite Tabs: The LONFLIT-FLITE randomized, controlled trial. Angiology. 2003;54:531-539.
17. Maurer HR. Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci. 2001;58:1234-1245.
18. Pirotta F, de Giuli-Morghen C. Bromelain: antiinflammatory and serum fibrinolytic activity after oral administration in the rat. Drugs Exp Clin Res. 1978;4:1-20.
19. Ako H, Cheung AH, Matsuura PK. Isolation of a fibrinolysis enzyme activator from commercial bromelain. Arch Int Pharmacodyn Ther. 1981;254(1):157-167.
20. Maurer HR, Eckert K, Grabowska E, Eschmann K. Use of bromelain proteases for inhibiting blood coagulation. Patent WO PCT/EP 98/04406. 2000.
21. De-Giuli M, Pirotta F. Bromelain, interaction with some protease inhibitor and rabbit specific antiserum. Drugs Exp Clin Res. 1978;4:21-23.
22. Smyth RD, Brennan R, Martin GJ. Systemic biochemical changes following the oral administration of a proteolytic enzyme, bromelain. Arch Int Pharmacodyn. 1962;136:230-236.
23. Taussig SJ. The mechanism of the physiological action of bromelain. Med Hypotheses. 1980;6(1):99-104.
24. Felton GE. Fibrinolytic and antithrombotic action of bromelain may eliminate thrombosis in heart patients. Med Hypotheses. 1980;6(1):1123-1133.
25. Sandhya KV, Devi SG, Mathew ST. Quantitation of serrapeptase in formulations by UV method in the microplate format. Curr Drug Deliv. 2008;5(4):303-305.
26. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: A multicentre, doubleblind, randomized trial versus placebo. J Int Med Res. 1990;18:379-388.
27. Sobel RA, Mitchell ME. Fibronectin in multiple sclerosis lesions. Am J Pathol. 1989;135:161-168.
28. Gveric D, Hanemaaijer R, Newcombe J, van Lent NA, Sier CF, Cuzner ML. Plasminogen activators in multiple sclerosis lesions: implications for the inflammatory response and axonal damage. Brain. 2001;124(Pt 10):1978-1988.
29. Pretorius E, Oberholzer HM. Ultrastructural changes of platelets and fibrin networks in human asthma: a qualitative case study. Blood Coagul Fibrinolysis. 2009;20(2):146-149.
30. Akassoglou K, Adams RA, Bauer J, et al. Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis. Proc Natl Acad Sci USA. 2004;101(17):6698-6703.
31. Bardos H, Molnar P, Csecsei G, Adany R. Fibrin deposition in primary and metastatic human brain tumours. Blood Coagul Fibrinolysis. 1996;7:536-548.

 

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Clinical Studies

 

The End of Heart Disease & Arthritis

Discovery Health Channel host Laurent Bannock, D.Sc., has completed a multi-patient study at the Santa Fe Cente for Nutritional Medicine in Santa Fe, New Mexico, to examine the ability of Neprinol to help the body maintain healthy fibrin activity and inflammation levels.

Dr. Bannock has published detailed clinical reports that provide evidence of Neprinol’s ability to help aging patients maintain healthy fibrin and inflammation processes in the body. This is critical since fibrosis, which is the excess sclerotic production of fibrin, causes high inflammation, a significant cause of premature aging and a clear-cut dangerous health signal. His study results, thus far, deal particularly with patients who complained primarily of osteoarthritis symptoms, a known inflammatory condition, as well as the even more inflammatory rheumatoid arthritis and health challenges involving cholesterol and insulin response. Neprinol combines key enzymes and synergists, such as nattokinase, serrapeptase, papain, bromelain, rutin and lipase (with coenzyme Q10).

Fibrin blood clot - Neprinol

Excess Fibrin creates a blood clot

Systemic Enzyme Deficiency

There are thousands of catalytic processes taking place between tissues and fluids in living plants and animals each day. These processes can occur only as a result of enzymatic reactions. Ancient men and women received enzymes from their diet via vegetables, fruits and other raw foods, nature’s richest sources of enzymes. Unfortunately, however, even moderate temperatures at which most foods are cooked destroy enzymes. Although enzymes are found most active in raw foods, the majority of food consumed today is both processed and cooked at extremely high temperatures, reducing dietary enzyme levels even further. Enzyme deficiencies can lead to common health problems—such as circulatory disorders, cancer, arthritis and kidney disease. Young adults have far greater enzyme activity than older ones whose ability to manufacture enzymes diminishes with age. The aging body’s diminished enzyme activity is part of the reason that people age prematurely. Bannock’s work and many other studies that have been covered extensively in medical journals support the use of systemic oral enzymes as a healthy approach to keeping the heart, joints, brain and other organs functioning efficiently for as long as possible.

The “Dark Side” of Tissue Repair

When scientists examine the most age related illnesses including heart disease, stroke, cancer, diabetes, kidney disorders and arthritis—similar underlying causes can be found: All of these conditions are characterized by insidious sclerosis and fibrosis that is caused by the oversecretion of growth factors. Sclerosis is defined as a hardening of a bodily tissue (such as the coronary arteries, i.e., arteriosclerosis) or an increase of connective tissue at the expense of more active tissue. Meanwhile, fibrosis is very similar to sclerosis, involving development of excess fibrous tissue in an organ (such as kidney fibrosis). Fibrosis can be detected in a number of ways, but is most noticeable with the pain associated with high levels of inflammation. Health experts have different ways of measuring the progression of these unfavorable bodily processes. For example, Dr. Bannock uses digital video blood microscopy which shows doctors whether blood has excess fibrin, oxidative stress and excessive white blood cell counts. Such indicators almost always indicate rheumatoid and osteoarthritis, as well as other negative health conditions. C-reactive protein (CRP) measurements were taken to determine bodily inflammation levels of the patients in the study. Increased CRP levels are often an indication of unhealthy fibrin activity, causing the blood to abnormally clot, increasing risk of heart attacks and strokes. Doctors have also associated high CRP with increased risk for heart disease. Another test used in the study was measuring erythrocyte sedimentation rate (ESR). In this test a blood sample is taken and put in a tube with chemicals which prevent the blood from clotting. The tube is left to stand upright. The red blood cells (erythrocytes) gradually fall to the bottom of the tube as a “sediment.” The clear liquid plasma is left at the top. The ESR measures the rate at which the red blood cells separate from the plasma and fall to the bottom of a test tube. The rate is measured in millimeters per hour (mm/hr). If certain proteins cover red cells, these will stick to each other and cause the red cells to fall more quickly. A high ESR indicates inflammation somewhere in the body. With age also comes fibrosis. Wrinkling and elastosis (loss of skin elasticity) are all outer signs of fibrosis. What is happening on the outside of the body is happening on the inside, too—to arteries, kidneys, lungs and other tissues and organs. Both sclerosis and fibrosis proceed with almost uncanny determination by the time a person reaches 40 and eventually affect virtually every tissue and organ in the body.

Clinical Studies

The following case studies were taken from a larger six-month independent clinical study on Neprinol carried out by Dr. Bannock. CRP measurements, digital video blood microscopy, standard blood workups, as well as patients’ subjective assessments were taken to demonstrate the efficacy of Neprinol on the patients.

Understanding Live Blood Video Microscopy

Beaker - Neprinol

Neprinol Clinical Study Continued

 

 

 

Video microscopy of live and dried layered blood analysis is a unique technique used to formulate an appropriate course of natural health building and lifestyle principles to optimize health, prevent disease, and to monitor individual effectiveness. This technique uses live, not preserved blood, with higher magnification than conventional methods. The live blood images below and throughout the rest of this report reflect several types of live blood video microscopy. The first three images in each four-image set utilize phase contrast and dark field microscopy. In these, the clinician searches for fibrin spiculae, which should not appear in live blood at all. “It

indicates that the balance between hemostasis and fibrinolysis is too much in favor of clotting,” says Dr. Bannock. Additionally, cholesterol and mycoplasma organisms can also be viewed in the blood. The last image in each four-image set is Dried Layered Blood Analysis to examine the coagulation cascade. This application of viewing dried suspended blood samples offers the qualified analyst and client valuable clues to potential degenerative patterns. The use of digital microscopy and live blood analysis has been criticized by some of in medical community. The reason for this is two-fold. The interpretation of dark field images as well as the handling of the specimen must be done with great care to get accurate results. The use of blood analysis has little or no use when prescribing pharmaceutical drugs for the alleviation of arthritis and related conditions. This is mainly the reason it has not been widely accepted in the medical community. It is however a useful tool in clinical nutrition. Blood analysis helps pinpoint deficiencies and abnormalities in the blood. It is very effective for a nutritionist involved in prescribing the nutritional regiment to restore normal values that may otherwise seem normal.

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Initial Visit

Neprinol Case Study #1

Study Subject: 45-year-old male construction worker recently diagnosed with osteoarthritis.

Initial Visit

Subjective: Chronic pain and inflammation of the wrist and elbow joints (both arms). Uses over-the-counter ibuprofen for relief, regularly.

Objective: Lab tests showed very high C-reactive protein, high ESR, high platelets and high globulin values. Digital video blood microscopy showed significant protein polymerization (oxidative stress that causes high ESR levels), raised platelets, raised poikilocytes (variably shaped cells, which are seen in iron deficiency anemia), raised fibrin and raised white blood cells (WBCs, an indication of an unhealthy immune system).

Treatment: Three Neprinol capsules, twice a day, between meals. Advised to discontinue ibuprofen usage. No other medications or supplements were recommended (for the purposes of the study).

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2 Month Follow Up

Two Month Follow-Up Visit

Subjective: Still had some pain and inflammation of wrists and elbows, but reports symptoms to be markedly improved. Objective: Lab tests showed slightly raised C-reactive protein, high ESR, normal platelets, slightly raised globulin values. Digital video blood microscopy showed moderate protein polymerization (oxidative stress), slightly raised platelets, slightly raised poikilocytes, normal fibrin and slightly raised WBCs.

Treatment: Three Neprinol capsules, twice a day, between meals. Has discontinued ibuprofen usage.

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4 Month Follow Up

Four Month Follow-Up Visit

Subjective: Completely pain and inflammation free. No longer uses ibuprofen at all!

Objective: Lab tests showed normal C-reactive protein, slightly high ESR, normal platelets and normal globulin values. Digital video blood microscopy showed slight protein polymerization (oxidative stress), normal platelets, very few poikilocytes, no fibrin and normal white blood cells.

Treatment: Two Neprinol capsules twice daily, between meals.

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6 Month Follow Up

Six Month Follow-Up Visit

 

 

 

 

 

 

Subjective: Still completely pain and inflammation free.

Objective: Lab tests are normal. Digital video blood microscopy is normal.

Treatment: One Neprinol capsule twice daily, between meals.

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Lab Test Values (Blood) for Neprinol Osteoarthritis Case Study

 

Lab Test Initial Visit 2 Month Visit 4 Month Visit 6 Month Visit
C-reactive protein

<1.0 = Low

1.0 – 3.0 = Average

3.1 – 10.0 = High

>10 = Persist. Inflammation

 13.7 mg/L 11.4 mg/L 7.1 mg/L 2.8 mg/L
ESR

Normal Values for Males:

0-15 mm/hour

 17.3 mm/hour 16.7 mm/hour 15.2 mm/hour 9.4 mm/hour
Platelets

Normal Values:

155 – 385 x 103/mm3
 

397 x 103/mm3
 

353 x 103/mm3
 

316 x 103/mm3
 

317 x 103/mm3
Globulin

Normal Values:

2.0 – 3.9 g/dL

 4.2 g/dL 3.94 g/dL 3.16 g/dL 2.77 g/dL

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Initial-Visit-Rheumatoid

Neprinol Case Study #2

Study Subject: 67-year-old female retired administrator,diagnosed with rheumatoid arthritis five years ago.

Initial Visit

Subjective: Pain, inflammation and discomfort, and partial loss of all joint functions. has been using NSAIDs (non-steroidal anti-inflammatory drugs, such as aspirin or ibuprofen) since diagnosis five years ago. The NSAIDs only provide partial relief of symptoms. Has also been taking fish oils and glucosamine supplements for one year with some benefit to all symptoms

Objective: Lab tests showed high uric acid, high ESR, raised C-reactive protein and low albumin values. Digital video blood microscopy showed significant protein polymerization and fibrin.

Treatment: Five Neprinol capsules, three times daily, between meals. The subject continued existing meds and supplements.

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2-Month-Follow-Up-Visit-Rheumatoid

Two Month Follow-Up Visit

Subjective: Notices a difference by slight improvement in joint function and greater relief. Objective: Lab tests showed slightly improved ESR values, normal C-reactive protein, similar uric acid values and slightly improved (but still low) albumin values. Digital video blood microscopy showed a reduction in protein polymerization and a significant drop in fibrin.

Treatment: Five Neprinol capsules, three times daily, between meals. The subject continued existing meds and supplements.

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4-Month-Follow-Up-Rheumatoid

Four Month Follow-Up Visit

Subjective: Reports significant improvements in joint function and significant relief. Wants to try and come off NSAIDs.

Objective: Lab tests showed nearly normal ESR values, slightly high uric acid values, normal C-reactive protein and normal albumin values. Digital video blood microscopy showed slight protein polymerization and virtually no fibrin.

Treatment: Five Neprinol capsules, three times daily, between meals. The subject continued supplements and is starting to reduce NSAIDs.

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6-Month-Follow-Up-Visit-Rheumatoid

Six Month Follow-Up Visit

Subjective: Continues to notice improvements in joint function and relief of pain and inflammation. Has been off NSAIDs for one month. Reports that quality of life has significantly improved!

Objective: Lab tests showed that uric acid values are slightly high, with normal ESR, C-reactive protein and albumin values. Digital video blood microscopy is nearly normal with very slight polymerization.

Treatment: Five Neprinol capsules, three times daily, between meals. The subject continued supplements, and has discontinued NSAIDs.

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Lab Test Values (Blood) for Neprinol Rheumatoid Arthritis Case Study

 

Lab Test Initial Visit 2 Month Visit 4 Month Visit 6 Month Visit
Uric acid

2.2 – 7.7 mg/dL

 8.4 mg/dL 8.1 mg/dL 7.9 mg/dL 8.0 mg/dL
C-reactive protein

<1.0 = Low

1.0 – 3.0 = Average

3.1 – 10.0 = High

>10 = Persist. Inflammation

 6.4 mg/L 3.0 mg/L 2.7 mg/L 2.7 mg/L
ESR

Normal Values for Females:

0 – 20 mm/hour

 22.7 mm/hour 21.8 mm/hour 17.5 mm/hour 12.4 mm/hour
Albumin

Normal Values:

3.5 – 5.5 g/dL

 2.6 g/dL 2.9 g/dL 3.6 g/dL 4.0 g/dL

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About Enzymus Medical

About Enzymus Medical

Enzymus Medical is a fine purveyor of exotic and designer enzyme products. We are the preferred platinum reseller and distributor of Arthur Andrew Medical products.   We offer the lowest prices on Neprinol, AFD. Neprinol “Advanced Fibrin Defense” is currently the world’s strongest systemic enzyme. Enzymus Medical offers unique and innovative products and added value services.   Our specially qualified staff is always ready to assist our clients with healthy options and safe advice. Our philosophy is always to provide excellent service and first-rate support.  Our customer first approach and dedicated sales staff are eager to help you find the right product to satisfy your needs.   Our sales operators are available 24 hours a day 7 days a week to personally take your orders.  Should you have technical questions our highly trained customer service agents are available Monday through Friday from 8am -5pm Pacific.

Arthur Andrew Medical is an innovative and key manufacturer of designer and specialty enzymes based in Scottsdale Arizona.  Enzymus Medical has paired with Arthur Andrew Medical in an effort to combine the best enzymes and products with world class marketing and customer service.  Enzymus proudly services the needs of thousands of customers in counties all over the world.  Arthur Andrew Medical has over a decade of experience in designer enzymes, custom probiotics, and proprietary anti-oxidant formulations.  Their technical team consists of doctors, scientists, researchers and specialty engineers, all with broad and extensive knowledge of manufacturing and custom formulation.

Arthur Andrew Medical contracts some of the brightest and well-known enzymologists together with best in class materials pioneering advanced dietary and therapeutic supplements that can greatly enhance fitness as well as general health. In 2003 Arthur Andrew Medical developed Neprinol, currently the World’s strongest and most effective systemic enzyme.  Neprinol is now the company’s flagship product with over 30 million capsules sold world-wide.   Neprinol is a combination of selective and highly potent microbial and vegetable based enzymes including Serrapeptase and Nattokinase, as well as antioxidants formulated to support healthy circulatory, joint and immune function. Neprinol has been the enzyme of choice for many doctors and healthcare practitioners.  With its success Neprinol is now available over the counter at many leading grocery and health food chains across the country.

Daily Neprinol supplementation has proved to be beneficial for the growing population, as it helps to gradually decrease the symptoms of rapid aging.  As we age our digestive system is less efficient.  Much of the food we eat can slowly and steadily leak from our intestinal system into our circulatory system.  This condition is referred to as Leaky Gut Syndrome (LGS).  While this condition is less of a syndrome and more accurately described as simply an inevitable part of growing older it can still present many concerns.  As we age our natural enzyme production decreases.  Our body’s natural enzymes are what keep our blood thin and remove toxic material.  With age our blood naturally becomes thicker while LGS can aggravate this by allowing undigested food particles to enter the blood.  Hyper-viscous blood riddled with food particles can lead to all kinds of circulatory concerns including increased blood pressure and risk of cardiac event. Undigested food can aggravate the immune system and is usually the cause of many autoimmune conditions that arise with age including arthritis.  Enzymes like those in Neprinol help maintain healthy blood fibrin levels as well as digest the accumulation of food particles that enter the blood.  Many of today’s experts prescribe toxic NSAID’s like aspirin daily to prevent heart attack.  Aspirin is considered a blood thinner, but aspirin in fact does not actually thin the blood.  Neprinol can be a healthy addition to a normal diet to help maintain healthy blood factors and sustain healthy heart function.

If you have questions about Neprinol or any of our other products please visit www.enzymus.com or call us at 1-800-930-9833 and ask one of our highly trained sales staff to help you.  We value your support and look forward to serving you.

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